Deadly Iranian bombing hits central Israel in the toughest night since the outbreak of the war, according to Yedioth Ahronoth newspaper.

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The Israeli newspaper Yedioth Ahronoth described last night as "the most difficult" since the outbreak of the open confrontation with Iran, after a series of painful missile strikes targeted central Israel, causing deaths, injuries, and widespread damage, affecting vital and residential areas. One of the direct hits on the coastal city of Bat Yam resulted in the death of four people, including two children, while about 35 people are still missing as rescue and search operations continue under the rubble. More than 170 injuries were also recorded in the Gush Dan and Sharon Plain areas, including six serious cases. In the village of Tamra in the north of the country, a missile falling on a house led to the death of four women from one family, and the injury of about 20 people with varying injuries. The newspaper also revealed that the Weizmann Institute of Science in Rehovot was subjected to a barrage of Iranian missiles, and it was reported that one of the missiles caused a fire in its scientific laboratories, amid a state of panic in the region. Missiles were detected being launched from Yemen in conjunction with the attack, and sirens were activated in the Samaria and Sharon regions following reports of drone infiltration. On the other hand, the Israeli army announced, prior to the Iranian strike, the implementation of large-scale attacks in the capital, Tehran, targeting the infrastructure of the Iranian nuclear program, including the Ministry of Defense headquarters, the "SPND" site, and fuel depots, confirming that the attacks were carried out based on accurate intelligence information. In a statement to the Wall Street Journal, a senior Israeli official was quoted as saying: "All targets related to disrupting the Iranian nuclear program are on the table - including Supreme Leader Ali Khamenei." These developments indicate an unprecedented escalation that could push the region towards a comprehensive confrontation, with multiple parties entering the line of fire, amid increasing international warnings of the expansion of the conflict and its regional and humanitarian repercussions.